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Studies at clinically relevant doses have demonstrated that sertraline blocks the uptake of serotonin into human plateletsIn vitro studies in animals also suggest that sertraline is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptakeIn vitro studies have shown that sertraline has no significant affinity for adrenergicalpha1alpha2betacholinergicGABAdopaminergichistaminergicserotonergic5HT1A5HT1B5HT2or benzodiazepine receptorsThe chronic administration of sertraline was found in animals to down regulate brain norepinephrine receptorsSertraline does not inhibit monoamine oxidase.

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Zoloft is a medication known as a selective serotonin reuptake inhibitorThe mediation is used to treat major depressive disorderobsessive-compulsive disorderpanic disorderpost-traumatic stress disordersocial anxiety disorderand premenstrual dysphoric disorder.

Based on pharmacokinetic studiesno dosage adjustment of ZOLOFT is necessary when used in combination with cimetidineAdditionallyno dosage adjustment is required for diazepamlithiumatenololtolbutamidedigoxinand drugs metabolized by CYP3A4when ZOLOFT is administered concomitantlySee CLINICAL PHARMACOLOGY

Zoloft is a medication known as a selective serotonin reuptake inhibitorThe mediation is used to treat major depressive disorderobsessive-compulsive disorderpanic disorderpost-traumatic stress disordersocial anxiety disorderand premenstrual dysphoric disorder.

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