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The limited available data based on post-marketing reports are not sufficient to inform a drug-associated risk for major birth defects and miscarriage during pregnancythere are risks to the mother and fetus associated with poorly controlled hypertension in pregnancy.
The CHMP harmonised the contraindication as followshypersensitivityallergyto dihydropyridine derivativesamlodipine or to any of the excipientssevere hypotensionlow blood pressureshocka steep fall in blood pressureobstruction of the outflow tract of the left ventriclea chamber in the heartand patients with heart failure where to buy anafranil capsules. following a heart attack.
Dizzinesslightheadednessswelling ankles/feetor flushing may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.
CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.
As with other calcium channel blockershemodynamic measurements of cardiac function at rest and during exerciseor pacingin patients with normal ventricular function treated with Norvasc have generally demonstrated a small increase in cardiac index without significant influence on dP/dt or on left ventricular end diastolic pressure or volumeIn hemodynamic studiesNorvasc has not been associated with a negative inotropic effect when administered in the therapeutic dose range to intact animals and maneven when co-administered with beta-blockers to manSimilar findingshoweverhave been observed in normal or well-compensated patients with heart failure with agents possessing significant negative inotropic effects.
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