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Kidney function declines as you grow olderThis medication is removed by the kidneysThereforecaution is advised when using this drug in the elderly because they may be more sensitive to its side effectsespecially stomach bleeding and kidney problems.

Strategies to Minimize the GI Risks in NSAID-treated patients Use the lowest effective dosage for the shortest possible durationAvoid administration of more than one NSAID at a timeAvoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleedingFor such patientsas well as those with active GI bleedingconsider alternate therapies other than NSAIDsRemain alert for signs alldaychemist. and symptoms of GI ulceration and bleeding during NSAID therapyIf a serious GI adverse event is suspectedpromptly initiate evaluation and treatmentand discontinue Ponstel until a serious GI adverse event is ruled outIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxismonitor patients more closely for evidence of GI bleedingsee PRECAUTIONSDrug Interactions

Advise the patient to read the FDA-approved patient labelingMedication Guidethat accompanies each prescription dispensedInform patientsfamilies and their caregivers of the following information before initiating therapy with Ponstel and periodically during the course of ongoing therapy.

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