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In this study where pioglitazone dosage was kept constant, the combination therapy group showed dose-sparing effects with respect to prandin see figure 1 legend .

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Repaglinide had no clinically relevant effect on the pharmacokinetic properties of digoxintheophylline or warfarin at steady statewhen administered to healthy volunteersDosage adjustment of these compounds when co-administered with repaglinide is therefore not necessary.

The warning signs of a hypo may come on suddenly and can includecold sweatcool pale skinheadacherapid heart beatfeeling sickfeeling very hungrytemporary changes in visiondrowsinessunusual tiredness and weaknessnervousness or tremorfeeling anxiousfeeling confuseddifficulty in concentrating.

Based on in vitro datarepaglinide appears to be a substrate for active hepatic uptakeorganic anion transporting protein OATP1B1Substances that inhibit OATP1B1 may likewise have the potential to increase plasma concentrations of repaglinideas has been shown for ciclosporinsee below

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