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It is not known whether this drug is excreted in human milkBecause many drugs are excreted in human milkcaution should be exercised when rizatriptan are administered to women who are breastfeedingRizatriptan is extensively excreted in rat milkat a level of fivefold or greater than maternal plasma levels.

Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome.

The development of a potentially life-threatening serotonin syndrome may occur with triptansincluding rizatriptan treatmentparticularly during combined use with SSRIs or SNRIsIf concomitant treatment with rizatriptan and an SSRIe.gfluoxetineparoxetinesertralinefluvoxaminecitalopramescitalopramor SNRIe.gvenlafaxineduloxetineis clinically warrantedcareful observation of the patient is advisedparticularly during treatment initiation and dose increases or with addition of another serotonergic medicationSerotonin syndrome symptoms may include mental status changese.gagitationhallucinationsand comaautonomic instabilitye.gtachycardialabile blood pressureand hyperthermianeuromuscular aberrationse.ghyperreflexiaincoordinationand/or gastrointestinal symptomse.gnauseavomitingand diarrhoea

Factors that trigger this headache type are a muscle strainstress or anxiety.

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