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CarbamazepineVerapamil may increase carbamazepine concentrations during combined therapyThis may produce carbamazepine side free estrogen samples. effects such as diplopiaheadacheataxiaor dizziness.
Verapamil can slow down the removal of other medications from your bodywhich may affect how they workExamples of affected drugs include asunaprevircolchicineflibanserinivabradinelomitapidemidazolamtriazolamamong others.
Electrical activity through the AV node dependsto a significant degreeupon calcium influx through the slow channelBy decreasing the influx of calciumISOPTIN prolongs the effective refractory period within the AV node and slows AV conduction in a rate related manner.
This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.
Treatment of overdosage should be supportiveBeta adrenergic stimulation or parenteral administration of calcium solutions may increase calcium ion flux across the slow channeland have been used effectively in treatment of deliberate overdosage with verapamilContinued treatment with large doses of calcium may produce a responseIn a few reported casesoverdose with calcium channel blockers that was initially refractory to atropine became more responsive to this treatment when the patients received large dosesclose to 1 gram/hour for more than 24 hoursof calcium chlorideVerapamil cannot be removed by hemodialysisClinically significant hypotensive reactions or high degree AV block should be treated with vasopressor agents or cardiac pacingrespectivelyAsystole should be handled by the usual measures including cardiopulmonary resuscitation.
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