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An increase in the incidence of background findings of spermatocele with or without secondary changes such as epididymal hypospermia as well as minimal to slight dilation of the seminiferous tubules was seen in the juvenile ratThese reproductive findings while apparently treatment-related did not increase in incidence or severity with dose and may indicate an exacerbation of a spontaneous conditionSimilar reproductive findings were not observed in studies of juvenile or adult dogs or in adult rats treated with celecoxibThe clinical significance of this observation is unknown.
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Monitor blood pressureBPduring the initiation of NSAID treatment and throughout the course of therapy.
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