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Rizact is a selective serotonin receptor agonist used by those suffering from severe headaches or, more commonly, migraines.

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Make changes in your diet such as avoid such foodsincluding caffeine and alcohol which are believed to trigger headachesYou can also try muscle relaxation exercisesyoga or meditation to ease the migraine attack.

Triptanssuch as rizatriptanMaxaltor almotriptanAxertAntinausea medicinessuch as chlorpromazineThorazinepromethazinePhenerganor prochlorperazineCompazineNon-steroidal anti-inflammatory drugsNSAIDssuch as acetaminophennaproxen sodiumaspirin or ibuprofen.

The development of a potentially life-threatening serotonin syndrome may occur with triptansincluding rizatriptan treatmentparticularly during combined use with SSRIs or SNRIsIf concomitant treatment with rizatriptan and an SSRIe.gfluoxetineparoxetinesertralinefluvoxaminecitalopramescitalopramor SNRIe.gvenlafaxineduloxetineis clinically warrantedcareful observation of the patient is advisedparticularly during treatment initiation and dose increases or with addition of another serotonergic medicationSerotonin syndrome symptoms may include mental status changese.gagitationhallucinationsand comaautonomic instabilitye.gtachycardialabile blood pressureand hyperthermianeuromuscular aberrationse.ghyperreflexiaincoordinationand/or gastrointestinal symptomse.gnauseavomitingand diarrhoea

Rizatriptan should only be used where a clear diagnosis of migraine has been establishedRizatriptan should not be administered to patients with basilar or haemiplegic migraineAs with other 5-HT 1B1D agonistssensations of tightnesspainpressure and heaviness have been reported after treatment with rizatriptan in the precordiumthroatneck and jawThese events have not been associated with arrhythmias or definite ischaemic electrocardiogramECGchanges in clinical trialsone patient experienced chest pain with possible ischaemic ECG changesBecause drugs in this class may cause coronary artery vasospasmpatients who experience signs or symptoms suggestive of angina following dosing should be evaluated for the presence of coronary artery diseaseCADor a predisposition to Prinzmetal’s variant angina before receiving additional doses of medicationand should be monitored by ECG if dosing is resumed and similar symptoms recurSimilarlypatients who experience other symptoms or signs suggestive of decreased arterial flowsuch as ischaemic bowel syndrome or Raynaud’s syndrome following the use of any 5-HT 1 agonist are candidates for further evaluation.

Ergot-containing drugs have been reported to cause prolonged vasospastic reactionsBecause there is a theoretical basis that these effects may be additiveuse of ergotamine-containing or ergot-type medicationslike dihydroergotamine or methysergideand rizatriptan within 24 hours is contraindicatedDue to an additive effectthe concomitant use of rizatriptan and ergotamine/ergot derivativesincluding methysergideincreases the risk of coronary artery vasoconstriction and hypertensive effectsThis combination is contraindicated.

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