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MAXZIDE should be used with caution in patients with impaired hepatic function or progressive liver diseasesince minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

This medicine may be prescribed for other usesask your doctor or pharmacist for more information.

The exact mechanism of hydrochlorothiazide’s antihypertensive action is not known although it may relate to the excretion and redistribution of body sodium.

Triamterene is a prescription drug indicated in the treatment of edema associated with congestive heart failurecirrhosis of the liver and the nephrotic syndromesteroid-induced edemaidiopathic edema and edema due to secondary hyperaldosteronism.

Triamterene is a potassium-conservingantikaliureticdiuretic with relatively weak natriuretic propertiesIt exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogenWith this actiontriamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazideTriamterene is not a competitive antagonist of the mineralocorticoids and its potassium-conserving effect is observed in patients with Addison’s diseasei.ewithout aldosteroneTriamterene’s onset and duration of activity is similar to hydrochlorothiazideNo predictable antihypertensive effect has been demonstrated with triamterene.

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