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On the other hand, dopamine d1 and d2 receptor antagonism influences hypothalamic npy mrna expression 117 119 and serotonin 5-ht2c receptor agonists can activate pomc neurons 120 , 121 , therefore, the antagonistic affinity of olanzapine to d2 and 5-ht2c receptors 122 , 123 may contribute to its weight gain side-effects 24 .

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Cerebrovascular effects includingstroke and transient ischemic attack resulting in death reported.

Olanzapine can be given without regards for meals as absorption is not affected by foodGradual tapering of the dose should be considered when discontinuing olanzapine.

A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMSreportedmanagement of NMS should include1immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy2intensive symptomatic treatment and medical monitoringand 3treatment of any concomitant serious medical problems for which specific treatments are availablethere is no general agreement about specific pharmacological treatment regimens for NMSif patient requires antipsychotic drug treatment after recovery from NMSpotential reintroduction of drug therapy should be carefully consideredpatient should be carefully monitoredsince recurrences of NMS reported.

Not approved for dementia-related psychosiselderly patients with dementia-related psychosis who are treated with antipsychotic drugs are at increased risk of deathas shown in short-term controlled trialsin these trialsdeaths appeared to be either cardiovasculare.gheart failuresudden deathor infectiouse.gpneumoniain nature.

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currently available data indicate that the mean increase in weight in adolescents is greater than in adults receiving olanzapine.

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