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Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effectsConcomitant use of carbamazepine and isoniazid has been reported to increase isoniazid-induced hepatotoxicityAlterations of thyroid function have been reported in combination therapy with other anticonvulsant medicationsConcomitant use of Tegretol with hormonal contraceptive productse.goraland levonorgestrel subdermal implant contraceptivesmay render the contraceptives less effective because the plasma concentrations of the hormones may be decreasedBreakthrough bleeding and unintended pregnancies have been reportedAlternative or back-up methods of contraception should be consideredResistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents pancuroniumvecuroniumrocuronium and cisatracurium has occurred in patients chronically administered carbamazepineWhether or not carbamazepine has the same effect on other nondepolarizing agents is unknownPatients should be monitored closely for more rapid recovery from neuromuscular blockade than expectedand infusion rate requirements may be higher.

A case of aseptic meningitisaccompanied by myoclonus and peripheral eosinophiliahas been reported in a patient taking carbamazepine in combination with other medicationsThe patient was successfully dechallengedand the meningitis reappeared upon rechallenge with carbamazepine.

Do not stop taking TEGRETOL without first talking to your healthcare provider.

Before prescribing Tegretolthe physician should be thoroughly familiar with the details of this prescribing informationparticularly regarding use with other drugsespecially those which accentuate toxicity potential.

A fully developed aplastic anemia will require appropriateintensive monitoring and therapyfor which specialized consultation should be sought.

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