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Metoclopramide should not be used whenever stimulation of gastrointestinal motility might be dangerouse.gin the presence of gastrointestinal hemorrhagemechanical obstructionor perforation.
In generalthe incidence of adverse reactions correlates with the dose and duration of metoclopramide administrationThe following reactions have been reportedalthough in most instancesdata do not permit an estimate of frequency:
Rarelycases of hepatotoxicitycharacterized by such findings as jaundice and altered liver function testswhen metoclopramide was administered with other drugs with known hepatotoxic potential.
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