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Three mechanisms of action have been postulated for the increased effectiveness of concomitant use of hydroxyurea therapy with irradiation on squamous cellepidermoidcarcinomas of the head and neckIn vitro studies utilizing Chinese hamster cells suggest that hydroxyurea1is lethal to normally radioresistant S-stage cellsand2holds other cells of the cell cycle in the G1 or pre-DNA synthesis stage where they are most susceptible to the effects of irradiationThe third mechanism of action has been theorized on the basis of in vitro studies of HeLa cellsIt appears that hydroxyureaby inhibition of DNA synthesishinders the normal repair process of cells damaged but not killed by irradiationthereby decreasing their survival rateRNA and protein syntheses have shown no alteration.
Adultsadminister 15 mg/kg by mouth once dailyDose adjustments are made based on patient’s blood countsPatient’s blood counts are monitored every two weeksIf the blood counts are in anacceptablerangethe dose may be increased by 5 mg/kg/day every 12 weeks until a maximum tolerated dosehighest dose that does not produce toxic blood countsor 35 mg/kg/day is reached.
There are a number of things you can do to manage the side effects of hydroxyureaTalk to your care team about these recommendationsThey can help you decide what will work best for youThese are some of the most common or important side effects:
Feverchillsbody achesflu symptomssores in your mouth and throateasy bruisingunusual bleedingnosemouthvaginaor rectumpurple or red pinpoint spots under your skinpale skinfeeling light-headed or short of breathrapid heart ratetrouble concentratingskin rednessskin ulcersor open.
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