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Smoking is associated with an increase in CYP1A2 activityAfter cessation of smokingreduced clearance of medicinal products metabolised by this enzymewith subsequent increases in plasma levelsmay occurThis may be particularly important for those medicinal products primarily metabolised by CYP1A2 with narrow therapeutic windowse.gtheophyllinetacrine and clozapineThe clinical consequences of smoking cessation on other medicinal products that are partially metabolised by CYP1A2e.gimipramineolanzapineclomipramineand fluvoxamineare unknownIn additionlimited data indicate that the metabolism of flecainide or pentazocine may also be induced by smoking.

Tell your doctor if you are not able to stop smoking after 7 to 12 weeks on this medication.

Zyban is intended for oral use onlyThe inhalation of crushed tablets or injection of dissolved bupropion has been reportedand may lead to a rapid releasefaster absorption and a potential overdoseSeizures and/or cases of death have been reported when bupropion has been administered intra-nasally or by parenteral injection.

Zybanbupropionis a prescription medication that can be used to stop smoking.

In patients receiving medicinal products known to lower the seizure thresholdZyban must only be used if there is a compelling clinical justification for which the potential medical benefit of smoking cessation outweighs the increased risk of seizuresee section 4.4

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