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Severe cutaneous reactionsincluding Stevens-Johnson syndromeepidermal necrolysisand drug rash with eosinophilia and systemic symptomsDRESSreporteddiscontinue therapy and implement supportive therapy if reaction occurs.
Hypersensitivity reactionAnaphylactic/anaphylactoid reactionsincluding shock and fatalitieshave been reported with the use of cefiximeBefore therapy with SUPRAX is institutedcareful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporinspenicillinsor other drugsDiscontinue use if a reaction occursClostridium difficile associated diarrheaEvaluate if diarrhea occursDose Adjustment in Renal ImpairmentThe dose of SUPRAX should be adjusted in patients with renal impairment and those undergoing continuous ambulatory peritoneal dialysis and hemodialysisCoagulation EffectsCephalosporinsincluding SUPRAXmay be associated with a fall in prothrombin activityProthrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicatedPhenylketonuricsSUPRAX Chewable Tablets contain aspartamea source of phenylalanine.
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
May cause acute renal failure including tubulointerstitial nephritisdiscontinue therapy if renal failure occurs and initiate supportive therapy.
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