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All SSRIsincluding fluvoxamineshould not be taken with any of the monoamine oxidase inhibitorMAOIclass of antidepressants such as isocarboxazidMarplanphenelzineNardiltranylcypromineParnateand procarbazineMatulaneother drugs that inhibit monoamine oxidase such as linezolidZyvoxand intravenous methylene blueSuch combinations may lead to confusionhigh blood pressuretremorand increased activityFluvoxamine should not be administered within 14 days of discontinuing an MAO inhibitorand MAO inhibitors should not be administered within 14 days of stopping fluvoxamineSimilar reactions occur if fluvoxamine is combined with other drugsfor exampletryptophanStJohn’s wortmeperidineDemeroland tramadolUltramthat increase serotonin in the brainFluvoxamine can inhibit the elimination of clozapineClozarilnecessitating dosage reductions of clozapineFluvoxamine also may inhibit the elimination and increase the blood levels of theophyllineTheodurUniphylalprazolamXanaxand triazolamHalcionleading to side effects from these drugsFluvoxamine may increase the effect of warfarinCoumadinJantovenleading to excessive bleedingWarfarin therapy should be monitored more frequently in patients who also are taking fluoxetineCombining SSRIs with aspirinnonsteroidal anti-inflammatory drugs or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleedingFluvoxamine may increase blood levels of tizanidineZanaflexthioridazineMellarilalosetronLotronexand pimozideOrapleading to increased side effects of these drugs.

Liver or kidney diseaseheart diseasehigh blood pressureor a history of strokea bleeding or blood clotting disorderseizures or epilepsybipolar disordermanic depressionlow levels or sodium in your bloodan electrolyte imbalanceor if you are being treated with methylene blue injection.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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