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When colesevelam is coadministered with glyburide, maximum plasma concentration and total exposure to glucovance mite is reduced.

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Metformin is negligibly bound to plasma proteins and isthereforeless likely to interact with highly protein-bound drugs such as salicylatessulfonamideschloramphenicoland probenecidas compared to the sulfonylureaswhich are extensively bound to serum proteins.

In healthy volunteersthe pharmacokinetics of metformin and propranololand metformin and ibuprofen were not affected when coadministered in single-dose interaction studies.

Many drugs can interact with glyburide and metforminmaking this medicine less effective or increasing your risk of lactic acidosisThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed hereTell your doctor about all your current medicines and any medicine you start or stop using.

Take Glucovance exactly as prescribed by your doctorFollow all directions on your prescription label and read all medication guides or instruction sheetsYour doctor may occasionally change your doseUse the medicine exactly as directed.

Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are providedsee DOSAGE AND ADMINISTRATIONCONTRAINDICATIONSand PRECAUTIONS

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