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AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.
Taste disturbanceincluding taste losshas been reported with the use of Lamisil TabletsIt can be severe enough to result in decreased food intakeweight lossanxietyand depressive symptomsTaste disturbance may resolve within several weeks after discontinuation of treatmentbut may be prolongedgreater than 1 yearor may be permanentIf symptoms of a taste disturbance occurLamisil Tablets should be discontinued.
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Terbinafinean allylamine antifungalinhibits biosynthesis of ergosterolan essential component of fungal cell membranevia inhibition of squalene epoxidase enzymeThis results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiencyDepending on the concentration of the drug and the fungal species test in vitroterbinafine hydrochloride may be fungicidalHoweverthe clinical significance of in vitro data is unknown.
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