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Due to the alpha 1receptor blocking activity of labetalol HClblood pressure is lowered more in the standing than in the supine positionand symptoms of postural hypotension2including rare instances of syncopecan occurFollowing oral administrationwhen postural hypotension has occurredit has been transient and is uncommon when the recommended starting dose and titration increments are closely followedsee DOSAGE AND ADMINISTRATIONSymptomatic postural hypotension is most likely to occur 2 to 4 hours after a doseespecially following the use of large initial doses or upon large changes in dose.

Our TrandatelabetalolSide Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Exacerbation of angina andin some casesmyocardial infarction and ventricular dysrhythmias have been reported after abrupt discontinuation of therapy with beta-adrenergic blocking agents in patients with coronary artery diseaseAbrupt withdrawal of these agents in patients without coronary artery disease has resulted in transient symptomsincluding tremulousnesssweatingpalpitationheadacheand malaiseSeveral mechanisms have been proposed to explain these phenomenaamong them increased sensitivity to catecholamines because of increased numbers of beta receptors.

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