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It is recommended that liver enzyme tests be performed before the initiation of CRESTOR and if signs or symptoms of liver injury occurAll patients treated with CRESTOR should be advised to promptly report any symptoms that may indicate liver injuryincluding fatigueanorexiaright upper abdominal discomfortdark urine or jaundice.

There have been rare reports of immune-mediated necrotizing myopathyIMNMan autoimmune myopathyassociated with statin useIMNM is characterized byproximal muscle weakness and elevated serum creatine kinasewhich persist despite discontinuation of statin treatmentmuscle biopsy showing necrotizing myopathy without significant inflammationimprovement with immunosuppressive agents.

The CRESTOR tablet should be swallowed wholeDo not take 2 doses of CRESTOR within 12 hours of each other.

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