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Leukopenia Thrombocytopenia Tumor cell infiltration of bone marrow Previous X-ray therapy Previous therapy with other cytotoxic agents Impaired hepatic function Impaired renal function.

Alopecia occurs commonly in patients treated with cyclophosphamideThe hair can be expected to grow back after treatment with the drug or even during continued drug treatmentthough it may be different in texture or colorSkin rash occurs occasionally in patients receiving the drugPigmentation of the skin and changes in nails can occurVery rare reports of Stevens-Johnson syndrome and toxic epidermal necrolysis have been received during postmarketing surveillancedue to the nature of spontaneous adverse event reportinga definitive causal relationship to cyclophosphamide has not been established.

Malignant lymphomasStages III and IV of the Ann Arbor staging systemHodgkin’s diseaselymphocytic lymphomanodular or diffusemixed-cell type lymphomahistiocytic lymphomaBurkitt’s lymphoma multiple myeloma leukemiaschronic lymphocytic leukemiachronic granulocytic leukemiait is usually ineffective in acute blastic crisisacute myelogenous and monocytic leukemiaacute lymphoblasticstem-cellleukemiacyclophosphamide given during remission is effective in prolonging its durationmycosis fungoidesadvanced diseaseneuroblastomadisseminated diseaseadenocarcinoma of the ovary retinoblastoma carcinoma of the breast.

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