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Some dental or surgical procedures may necessitate the interruption or change in the dose of COUMADIN therapyConsider the benefits and risks when discontinuing COUMADIN even for a short period of timeDetermine the INR immediately prior to any dental or surgical procedureIn patients undergoing minimally invasive procedures who must be anticoagulated prior toduringor immediately following these proceduresadjusting the dosage of COUMADIN to maintain the INR at the low end of the therapeutic range may safely allow for continued anticoagulation.

Hemorrhagic tendencies or blood dyscrasias Recent or contemplated surgery of the central nervous system or eyeor traumatic surgery resulting in large open surfacessee WARNINGS AND PRECAUTIONSBleeding tendencies associated withActive ulceration or overt bleeding of the gastrointestinalgenitourinaryor respiratory tract Central nervous system hemorrhage Cerebral aneurysmsdissecting aorta Pericarditis and pericardial effusions Bacterial endocarditis Threatened abortioneclampsiaand preeclampsia Unsupervised patients with conditions associated with potential high level of non-compliance Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding Hypersensitivity to warfarin or to any other components of this producte.ganaphylaxissee ADVERSE REACTIONSMajor regional or lumbar block anesthesia Malignanthypertension.

As with most drugsat room temperatureaway from extreme coldheatlightand moisture is bestBathroom cabinets are usually NOT a good place for storing medications because of dampness.

Inhibitors of CYP2C91A2and/or 3A4 have the potential to increase the effectincrease INRof warfarin by increasing the exposure of warfarinInducers of CYP2C91A2and/or 3A4 have the potential to decrease the effectdecrease INRof warfarin by decreasing the exposure of warfarin.

Frequency not reportedCerebral hemorrhagecerebral subdural hematomalethargyheadachedizzinesstaste perversionparesthesiaRef]

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