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Cefadroxila first-generation cephalosporin antibioticis used to treat urinary tract infectionsskin and skin structure infectionspharyngitisand tonsillitis.

Pre-clinical data reveal no special hazard for humans based on conventional studies of repeated dose toxicitygenotoxicity and toxicity to reproduction.

Positive direct Coombstests have been reported during treatment with the cephalosporin antibioticsIn hematologic studies or in transfusion cross-matching procedures when antiglobulin tests are performed on the minor side or in Coombstesting of newborns whose mothers have received cephalosporin antibiotics before parturitionit should be recognized that a positive Coombstest may be due to the drug.

Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis through inactivation of one or more penicillin-binding proteins and inhibiting cross-linking of the peptidoglycan structureThe cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.

Generic NameCefadroxil Capsules and TabletsSEFF ah DROX ilBrand NameDuricef.

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