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You should talk with your doctor about your individual risks before using estrace for a prolonged period of time.

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This includes prescription and nonprescription medicinesvitaminsand herbal supplementsSome medicines may affect how Estrace worksEstrace may also affect how your other medicines work.

The distribution of exogenous estrogens is similar to that of endogenous estrogensEstrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organsEstrogens circulate in the blood largely bound to sex hormone binding globulinSHBGand albumin.

Circulating estrogens modulate the pituitary secretion of the gonadotropinsluteinizing hormoneLHand follicle-stimulating hormoneFSHthrough a negative feedback mechanismEstrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.

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