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This medication may rarely cause an inflammation of the heart musclemyocarditisor heart failureGet medical help right away if you develop chest painfast/irregular heartbeatshortness of breathswelling ankles/feetunusual tirednessor unusual/sudden weight gain.

Concomitant use of lithium or other CNS-active agents may increase the risk of development of neuroleptic malignant syndromeNMS

It may take several weeks before the full benefit of this drug takes effectInform your doctor if your condition persists or worsens.

This medication may rarely cause a very serious condition called neuroleptic malignant syndromeNMSGet medical help right away if you have any of the following symptomsfevermuscle stiffness/pain/tenderness/weaknesssevere tirednesssevere confusionsweatingfast/irregular heartbeatdark urinesigns of kidney problemssuch as change in the amount of urine

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythmBefore using clozapinetell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

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