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Reports usually indicate that furosemide ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.

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Approximately 65of furosemide is excreted unchanged in the urineand the remainder is conjugated to glucuronic acid in the kidneyAccordinglyin patients with renalbut not liverdiseasethe elimination half-life of furosemide is prolongedThe elimination half-life is short.

LasixFurosemideis one of the most commonly prescribed medications for the treatment of hypertensionwhich is accompanied by massive swellingThe therapeutic effectiveness of this medication has been confirmed by data reported in clinical trialsIn most casesLasix is used as one of the primary components involved in the complex therapy for essential hypertension.

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drug displacement studies have been performed in vitro between this highly bound drug 96 and other drugs such as furosemide, digoxin, and warfarin.

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