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The mechanism of action of VOLTARENlike that of other NSAIDsis not completely understood but involves inhibition of cyclooxygenaseCOX-1 and COX-2

Correct volume status in dehydrated or hypovolemic patients prior to initiating VOLTARENMonitor renal function in patients with renal or hepatic impairmentheart failuredehydrationor hypovolemia during use of VOLTARENsee DRUG INTERACTIONSAvoid the use of VOLTAREN in patients with advanced renal disease unless the benefits are expected to outweigh the risk of worsening renal functionIf VOLTAREN is used in patients with advanced renal diseasemonitor patients for signs of worsening renal function.

Diclofenac is 100absorbed after oral administration compared to IV administration as measured by urine recoveryHoweverdue to first-pass metabolismonly about 50of the absorbed dose is systemically availablesee Table 1Food has no significant effect on the extent of diclofenac absorptionHoweverthere is usually a delay in the onset of absorption of 1 to 4.5 hours and a reduction in peak plasma levels of.

If you become pregnant whilst taking or using Voltarentell your doctor immediatelyYour doctor can discuss with you the risks of using it while you are pregnant.

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retard voltaren belongs to a group of medicines called non-steroidal anti-inflammatory drugs nsaids , which are used to treat pain and inflammation.

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