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Concomitant administration of oral metronidazole and intravenous phenytoin was reported to result in prolongation of the half-life and reduction in the clearance of phenytoinMetronidazole did not significantly affect the pharmacokinetics of orally-administered phenytoin.

The plasma half-life of tinidazole is approximately 12-14 hoursTinidazole is excreted by the liver and the kidneysTinidazole is excreted in the urine mainly as unchanged drugapproximately 20-25of the administered doseApproximately 12of the drug is excreted in the feces.

Rare reported adverse reactions include bronchospasmdyspneacomaconfusiondepressionfurry tonguepharyngitis and reversible thrombocytopenia.

Vaginal itching or dischargenauseavomitingloss of appetiteindigestionconstipationdiarrheastomach crampsfeeling weak or tiredheadachedizzinessor a metallic or bitter taste in your mouth;

A medicine similar to tinidazole has caused cancer in laboratory animalsIt is not known if tinidazole would have the same effect in animalsor in humansTalk with your doctor about your individual risk.

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