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Atolip 10 MG Tablt blongs ta goup dugs known as “statins”. It ducs th lvl low dnsity lipopotin “bad cholstol” in th body. It alshlps in cuing vaious conditions lik naowing atis that aiss du tth high cholstol lvls in th body. It can alsduc th amount liv at in th body. This dug is alsusd tlow th isk stok, hat attack coonay hat disass.
Atovastatin is a slctiv, comptitiv inhibit3-hydoxy-3-mthylglutayl-conzym A (HMG-CoA) ductas, th at-limiting nzym that convts 3-HMG-CoA tmvalonat, a pcusstols, including cholstol. Cholstol and tiglycids (TG) ciculat in th bloodstam as pat lipopotin complxs. With ultacntiugation, ths complxs spaat inthigh-dnsity lipopotin (HDL), intmdiat-dnsity lipopotin (IDL), low-dnsity lipopotin (LDL) and vy-low-dnsity lipopotin (VLDL) actions. TG and cholstol in th liv a incopoatd intVLDL and lasd intth plasma dlivy tpiphal tissus. LDL is omd om VLDL and is catabolizd pimaily though th high-ainity LDL cpto.
Atovastatin, lik oth statins, occasionally causs myopathy, dind as muscl achs muscl waknss in conjunction with incass in catin phosphokinas (CPK) valus >10 tims ULN. Th concomitant us high doss atovastatin with ctain dugs such as cyclospoin and stong CYP3A4 inhibitos (.g., claithomycin, itaconazol, and HIV potas inhibitos) incass th isk myopathy/habdomyolysis.
Atovastatin, lik oth statins, occasionally causs myopathy, dind as muscl achs muscl waknss in conjunction with incass in catin phosphokinas (CPK) valus >10 tims ULN. Th concomitant us high doss atovastatin with ctain dugs such as cyclospoin and stong CYP3A4 inhibitos (.g., claithomycin, itaconazol, and HIV potas inhibitos) incass th isk myopathy/habdomyolysis.
Th ctivnss clopidogl is dpndnt on its activation tan activ mtabolit by th cytochom P450 (CYP) systm, pincipally CYP2C19. Clopidogl at commndd doss oms lss that mtabolit and has a small ct on platlt unction in patints wha CYP2C19 pomtabolizs. Pomtabolizs with acut coonay syndom undgoing pcutanous coonay intvntion tatd with clopidogl at commndd doss xhibit high cadiovascula vnt ats than dpatints with nomal CYP2C19 unction. Tsts a availabl tidntiy a patint’s CYP2C19 gnotyp; ths tsts can b usd as an aid in dtmining thaputic statgy. Consid altnativ tatmnt tatmnt statgis in patints idntiid as CYP2C19 pomtabolizs.
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