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Your doctor or healthcare provider should make sure that you are appropriately treated for any risk factors for heart disease such as high blood pressure, high cholesterol, diabetes, obesity, or smoking or blood clots before you take premarin tablets.

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Combined estrogen-progestogen and estrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic strokeThe relative risk does not change with age or time since menopauseHoweveras the baseline risk of stroke is strongly age-dependentthe overall risk of stroke in women who use HRT will increase with agesee section 4.8

A few cases of malignant transformation of residual endometrial implants have been reported in women treated post-hysterectomy with estrogen-alone therapyFor women known to have residual endometriosis post-hysterectomythe addition of progestin should be considered.

Premarin 0.3-1.25mg daily is the usual starting dose for women without a uterusContinuous administration is recommended.

Premarin may increase your risk of developing a condition that may lead to uterine cancerReport any unusual vaginal bleeding right away.

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