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Most common adverse reactions are gastrointestinal such as diarrhea16loose or frequent stools6abdominal pain3nausea7dyspepsia3and flatulence4Adverse reactions during postmarketing experience occurred at rates of less than 2Some serious adverse reactions includedpseudomembranous colitishypersensitivity reactions including Stevens-Johnson syndrome and serum sicknessacute renal failureseizuresagranulocytosisand toxic epidermal necrolysis.
Dosage must be adjusted in severe renal insufficiencyhigh doses may cause CNS toxicityincluding seizuressuperinfections and promotion of nonsusceptible organisms may occur with prolonged use or repeated therapy.
Indicated in the treatment of pharyngitis and tonsillitis caused by susceptible isolates of Streptococcus pyogenes.
In the treatment of infections due to Streptococcus pyogenesa therapeutic dosage of cefixime should be administered for at least 10 days.
GeriatricsAverage AUCs at steady state in elderly patients are approximately 40higher than average AUCs in other healthy adultsDifferences in the pharmacokinetic parameters between 12 young and 12 elderly subjects who received 400 mg of cefixime once daily for 5 days are summarized as follows:
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