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Clozaril can also improve symptoms related specifically to mania, including the following .

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Clozaril may enhance the central effects of CNS depressants such as narcoticsantihistamines and benzodiazepinesParticular caution is advised when Clozaril therapy is initiated in patients who are receiving a benzodiazepine or any other psychotropic agentThese patients may have an increased risk of circulatory collapsewhichon rare occasionscan be profound and may lead to cardiac and/or respiratory arrestIt is not clear whether cardiac or respiratory collapse can be prevented by dose adjustment.

Initial dose12.5 mg orally once or twice a day Titration and MaintenanceMay increase total daily dose in increments of 25 mg to 50 mg per day to a target dose of 300 mg to 450 mg per dayadministered in divided dosesby the end of week 2Subsequent dose increases can be in increments of up to 100 mg once or twice weeklyMaximum dose900 mg per day.

Tell your doctor if you are a descendent of Ashkenazi Jews because you may be at a higher risk for a drop in your white blood cells.

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medicines to treat psychiatric disorders, such as chlorpromazine thorazine , clozapine clozaril, fazaclo , haloperidol haldol , olanzapine zyprexa, symbyax , prochlorperazine compazine , risperidone risperdal , thiothixene navane , and others.

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