Pubmed 11752352 roy s, guo x, kelschenbach j, liu y, loh hh l attivazione in vivo di un mutante del recettore mu-oppioidi per naltrexone produce un potente effetto analgesico, ma nessuna tolleranza ruolo dell attivazione recettore mu e delta-blocco dei recettori nella tolleranza morfina.
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Alcohol-and opioid-dependent patientsincluding those taking REVIAshould be monitored for the development of depression or suicidal thinkingFamilies and caregivers of patients being treated with REVIA should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidalityand to report such symptoms to the patient’s healthcare provider.
To reduce the risk of precipitated withdrawal in patients dependent on opioidsor exacerbation of a preexisting subclinical withdrawal syndromeopioid-dependent patientsincluding those being treated for alcohol dependenceshould be opioid-freeincluding tramadolbefore starting REVIA treatmentAn opioid-free interval of a minimum of 7 to 10 days is recommended for patients previously dependent on short-acting opioids.
In the clinical studiestreatment with REVIA supported abstinenceprevented relapse and decreased alcohol consumptionIn the uncontrolled studythe patterns of abstinence and relapse were similar to those observed in the controlled studiesREVIA was not uniformly helpful to all patientsand the expected effect of the drug is a modest improvement in the outcome of conventional treatment.
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