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These preparations are recommended for intramuscular and intrasynovial injection in horses and dogsand intramuscular injection in catsDEPO-MEDROL Sterile Aqueous Suspension is available in two concentrations20 mg per mL and 40 mg per mL.

MEDROL Tabletslike prednisolone and other adrenocortical steroids is a potent therapeutic agent influencing the biochemical behavior of mostif not alltissues of the bodyBecause this anti-inflammatory steroid manifests little sodium-retaining activitythe usual early sign of cortisone or hydrocortisone overdosageieincrease in body weight due to fluid retentionis not a reliable index of overdosageHencerecommended dose levels should not be exceededand all animal patients receiving MEDROL should be under close medical supervisionAll precautions pertinent to the use of prednisolone apply to methylprednisoloneMoreoverthe veterinarian should endeavor to keep informed of current studies with MEDROL as they are reported in the veterinary literature.

Frequency not reportedVertigoabnormal fat depositsmalaisesterile abscessimpaired healingfatigueRef]

The action of DEPO-MEDROL Sterile Aqueous Suspension injected intrasynovially appears to be well localized since significant metabolic effects characteristic of systemic administration of adrenal steroids have not been observedIn a few instances mild and transient improvement of structures other than those injected have been reportedNo other systemic effects have been notedHoweverit is possible that mild systemic effects may occur following intrasynovial administrationand this possibility is greater the larger the number of structures injected and the higher the total dose employed.

MEDROL is indicated in dogs and cats with conditions known to be responsive to anti-inflammatory corticosteroidsincluding collagendermalallergicocularotic and musculoskeletalas well as various chronic or recurrent diseasesulcerative colitis and nephrosis

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