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Reports of tubulointerstitial nephritis with medullary calcification and cortical atrophy have been observed in patients with asymptomatic severe leukocyturia100 cellshigh power fieldPatients with asymptomatic severe leukocyturia should be followed closely and monitored frequently with urinalysesFurther diagnostic evaluation may be warrantedand discontinuation of CRIXIVAN should be considered in all patients with severe leukocyturia.

The dosage of CRIXIVAN should be reduced to 600 mg every 8 hours in patients with mild-tomoderate hepatic insufficiency due to cirrhosis.

Some drugs can interact with indinavirincreasing or decreasing its levels in your bodyIncreased drug levels can cause you to experience side effects or make pre-existing side effects worseOn the other handif drug levels become too lowHIV can develop resistance and your future treatment options may be reduced.

Indirect hyperbilirubinemia has occurred frequently during treatment with CRIXIVAN and has infrequently been associated with increases in serum transaminasessee also ADVERSE REACTIONSClinical Trials and Post-Marketing ExperienceIt is not known whether CRIXIVAN will exacerbate the physiologic hyperbilirubinemia seen in neonatesSee Pregnancy

For many people with HIVthe use of ART has increased their CD4cell counts and decreased the amount of HIV in their bloodviral loadThese beneficial effects help to reduce the risk of developing a life-threatening infectionNeither indinavir nor any other anti-HIV medication is a cure for HIVIt is therefore important that you do the following:

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