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What should i discuss with my healthcare provider before taking isoniazid and rifampin.

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Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use this medication only for the indication prescribed.

Isoniazid is a prodrug and must be activated by bacterial catalaseSpecficiallyactivation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complexOnce activatedisoniazid inhibits the synthesis of mycoloic acidsan essential component of the bacterial cell wallAt therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organismsSpecifically isoniazid inhibits InhAthe enoyl reductase from Mycobacterium tuberculosisby forming a covalent adduct with the NAD cofactorIt is the INH-NAD adduct that acts as a slowtight-binding competitive inhibitor of InhA.

Side effects other than those listed here may also occurTalk to your doctor about any side effect that seems unusual or that is especially bothersomeYou may report side effects to FDA at 1-800-FDA-1088.

Treatment of latent TB infection greatly reduces the risk that TB infection will progress to acitve disease.

Isoniazid is an antibioticIt prevents tuberculous bacteria from multiplying in the body.

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fixcom4 is consist of four pills including 150 mg of rifampicin, 75mg of isoniazid, 400 mg of pyrazinamide and 275 mg of ethambutol.

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