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Life-threatening cutaneous reactionsStevens-Johnson syndromeSJSand toxic epidermal necrolysisTENhave been reported with the use of piroxicam.

NSAIDsincluding piroxicamcan cause serious skin adverse reactions such as exfoliative dermatitisStevensJohnson SyndromeSJSand toxic epidermal necrolysisTENwhich can be fatalThese serious events may occur without warningInform patients about the signs and symptoms of serious skin reactionsand to discontinue the use of FELDENE at the first appearance of skin rash or any other sign of hypersensitivityFELDENE is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS

Before taking piroxicamtell your doctor or pharmacist if you are allergic to itor to aspirin or other NSAIDssuch as ibuprofennaproxencelecoxibor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

The best results in managing SJS and TEN come from early diagnosis and immediate discontinuation of any suspect drugEarly withdrawal is associated with a better prognosis.

Nonsteroidal anti-inflammatory drugsNSAIDscause an increased risk of serious cardiovascular thrombotic eventsincluding myocardial infarction and strokewhich can be fatalThis risk may occur early in treatment and may increase with duration of usesee WARNINGS AND PRECAUTIONSFELDENE is contraindicated in the setting of coronary artery bypass graftCABGsurgerysee CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS

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