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ZETIAadded to on-going statin therapysignificantly lowered total-CLDL-CApo Bnon-HDL-Cand TGand increased HDL-C compared with a statin administered alonesee Table 7LDL-C reductions induced by ZETIA were generally consistent across all statins.

In clinical studiesadministration of ezetimibe50 mg/day to 15 healthy subjects for up to 14 days40 mg/day to 18 patients with primary hyperlipidemia for up to 56 daysand 40 mg/day to 27 patients with homozygous sitosterolemia for 26 weeks was generally well toleratedOne female patient with homozygous sitosterolemia took an accidental overdose of ezetimibe 120 mg/day for 28 days with no reported clinical or laboratory adverse events.

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