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You are pregnantmight become pregnant or think you may be pregnantYou are breast-feeding or planning to breast-feedThis is because small amounts may pass into mothersmilkBreast feeding while using oxybutynin is therefore not recommended.

At total daily doses ranging from 5 mg to 15 mgtreatment with DITROPAN Tablets was associated with an increase from baseline in mean urine volume per catheterization from 122 mL to 145 mLan increase from baseline in mean urine volume after morning awakening from 148 mL to 168 mLand an increase from baseline in the mean percentage of catheterizations without a leaking episode from 43to 61Urodynamic results in these patients were consistent with the clinical resultsTreatment with DITROPAN Tablets was associated with an increase from baseline in maximum cystometric capacity from 230 mL to 279 mLa decrease from baseline in mean detrusor pressure at maximum cystometric capacity from 36 cm H2O to 33 cm H2Oand a reduction in the percentage of patients demonstrating uninhibited detrusor contractionsof at least 15 cm H2Ofrom 39to 20

Antimuscarinic activity resides predominately in the R-isomerA metabolitedesethyloxybutyninhas pharmacological activity similar to that of oxybutynin in in vitro studies.

Stop using oxybutynin and call your doctor at once if you have a serious side effect such as:

4Yarker Y et alOxybutyninA review of its Pharmacodynamic and Pharmacokinetic Propertiesand its Therapeutic Use in Detrusor InstabilityDrugsAging19956(3243-262.

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