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Following a single 1-gram oral dosemean peak plasma levels ranging from 10-20 mcg/mL have been reportedPeak plasma levels are attained in 2 to 4 hours and the elimination half-life approximates 2 hoursFollowing multiple dosesplasma levels are proportional to dose with no evidence of drug accumulationIn a multiple dose trial of normal adult subjectsn=6receiving 1-gram doses of mefenamic acid four times dailysteady-state concentrations of 20 mcg/mL were reached on the second day of administrationconsistent with the short half-life.

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There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID useThe concurrent use of aspirin and an NSAIDsuch as mefenamic acidincreases the risk of serious gastrointestinalGIeventssee WARNINGSGastrointestinal BleedingUlcerationand Perforation

Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto mefenamic acid or any components of the drug productsee WARNINGSAnaphylactic ReactionsSerious Skin ReactionsHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDs have been reported in such patientssee WARNINGSAnaphylactic ReactionExacerbation of Asthma Related to Aspirin SensitivityIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGSCardiovascular Thrombotic Events

Taking an NSAID can increase your risk of life-threatening heart or circulation problemsincluding heart attack or strokeThis risk will increase the longer you use an NSAIDDo not use this medicine just before or after having heart bypass surgeryalso called coronary artery bypass graftor CABG

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no information is available for controlled studies regarding the use of ponstel mefenamic acid in patients with advanced renal disease.

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