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Paralysis/tetraparesis was reported in a patient taking this drug and colchicine concurrentlyRef]

Isoptin SRverapamil HCIis indicated for the management of essential hypertension.

Approximately 15of patients who had atrial flutter/fibrillation and received this drug and digoxin developed resting ventricular rates below 50 beats/minin the same trialasymptomatic hypotension occurred in approximately 5of patients.

Electrical activity through the AV node dependsto a significant degreeupon calcium influx through the slow channelBy decreasing the influx of calciumISOPTIN prolongs the effective refractory period within the AV node and slows AV conduction in a rate related manner.

Accessory Bypass TractWolff-Parkinson-White or Lown-Ganong-LevineSome patients with paroxysmal and/or chronic atrial fibrillation or atrial flutter and a coexisting accessory AV pathway have developed increased antegrade conduction across the accessory pathway bypassing the AV nodeproducing a very rapid ventricular response or ventricular fibrillation after receiving intravenous verapamilor digitalisAlthough a risk of this occurring with oral verapamil has not been establishedsuch patients receiving oral verapamil may be at risk and its use in these patients is contraindicatedsee CONTRAINDICATIONS

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