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The use of tegretol is contraindicated in combination with monoamine-oxidase inhibitors maois , before administering tegretol maois should be discontinued for a minimum of 2 weeks, or longer if the clinical situation permits see contraindications .

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Carbamazepine mustthereforebe considered to be carcinogenic in Sprague-Dawley ratsBacterial and mammalian mutagenicity studies using carbamazepine produced negative resultsThe significance of these findings relative to the use of carbamazepine in humans isat presentunknown.

Coadministration of carbamazepine and nefazodone may result in insufficient plasma concentrations of nefazodone and its active metabolite to achieve a therapeutic effectCoadministration of carbamazepine with nefazodone is contraindicated.

Gastric lavageEven when more than 4 hours have elapsed following ingestion of the drugthe stomach should be repeatedly irrigatedespecially if the patient has also consumed alcohol.

Dialysis is indicated only in severe poisoning associated with renal failureReplacement transfusion is indicated in severe poisoning in small children.

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