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Interpretations of in vivo studies suggest that ketoconazole impairs the synthesis of ergosterolwhich is a vital component of fungal cell membranesIt is postulatedbut not proventhat the therapeutic effect of ketoconazole in tineapityriasisversicolor is due to the reduction of Pityrosporum orbiculareMalassezia furfurand that the therapeutic effect in dandruff is due to the reduction of Pityrosporum ovaleSupport for the therapeutic effect in tinea versicolor comes from a three-armparalleldouble-blindplacebo controlled study in patients who had moderately severe tineapityriasisversicolorSuccessful response rates in the primary efficacy population for each of both three-day and single-day regimens of ketoconazole 2shampoo were statistically significantly greater73and 69respectivelythan a placebo regimen5There had been mycological confirmation of fungal disease in all cases at baselineMycological clearing rates were 84and 78respectivelyfor the three-day and one-day regimens of the 2shampoo and 11in the placebo regimenWhile the differences in the rates of successful response between either of the two active treatments and placebo were statistically significantthe difference between the two active regimens was not.

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