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Corticosteroids may mask some signs of infectionand new infections may appear during their useThere may be decreased resistance and inability to localize infection when corticosteroids are usedIf an infection occurs during fludrocortisone acetate therapyit should be promptly controlled by suitable antimicrobial therapy.
The approximate plasma half-life of fludrocortisonefluorohydrocortisoneis 3.5 hours or more and the biological half-life is 18 to 36 hours.
Corticosteroids are thought to actat least in partby controlling the rate of synthesis of proteinsAlthough there are a number of instances in which the synthesis of specific proteins is known to be induced by corticosteroidsthe links between the initial actions of the hormones and the final metabolic effects have not been completely elucidated.
The recommended dosage for treating the salt-losing adrenogenital syndrome is 0.1 mg to 0.2 mg of Florinef Acetate daily.
0.05-0.1 mg/day PO in single daily dose or divided q12hr in combination with sodium chloride supplementation.
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use of fludrocortisone acetate florinef for treating postural orthostatic hypotension is off label because it does not have a uk marketing authorisation for this indication, but it does have marketing authorisation for other indications.