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May increase risk of urinary retention in patients with bladder flow obstructionegbenign prostatic hypertrophy)

During pregnancythis medication should be used only when clearly neededDiscuss the risks and benefits with your doctor.

Tolterodine belongs to a class of drugs called cholinergicacetylcholinereceptor blockersIt is used to treat disorders of the urinary bladder that affect urinationThe urinary bladder is a muscularbagUrine coming from the kidneys fills the bladder and causes it to stretch like a balloonAs it stretchespressure in the bladder increases andwhen the bladder reaches a certain level of stretcha desire to urinate is feltNerves in the muscular wall of the bladder release acetylcholinea chemical that attaches to receptors on the muscle cells and causes the cells to contracttightenThis contributes further to the increase in pressure within the bladder and the desire to urinateAt the appropriate timefor examplewhen a toilet is availablethere is conscious relaxation of the muscle at the outlet of the bladderand the high bladder pressure forces urine out of the bladderNormallyurination is under conscious controlhoweverin some individuals normal control as well as normal sensation are lostThe desire to urinate may be felt when there is little urine in the bladderand urination may occur without warning or controlBy blocking the effect of acetylcholine on the muscle cellstolterodine slows the build-up of pressure in the bladderreduces the sensation to urinateand prevents uncontrolled urinationThe FDA approved tolterodine in 1998An extended release form of tolterodineDetrol LAwas approved by the FDA in 2001.

Table 5Incidenceof Adverse Events Exceeding Placebo Rate and Reported in1of Patients Treated with DETROL Tablets2 mg bidin 12-weekPhase 3 Clinical Studies.

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