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Patints civing Avodat should hav a nw PSA baslin stablishd at 6 months tatmnt with Avodat. It is commndd tmonitPSA valus gulaly that. Any conimd incas om lowst PSA lvl whil on Avodat may signal th psnc postat canc noncomplianc tthapy with Avodat and should b caully valuatd, vn i thos valus a still within th nomal ang mn not taking a 5-alpha ductas inhibit(s sction 5.1). In th intptation a PSA valu a patint taking Avodat, pvious PSA valus should b sought compaison.

Th commndd dos Avodat is on capsul (0.5 mg) takn oally onc a day. Th capsuls should b swallowd whol and not chwd opnd as contact with th capsul contnts may sult in iitation th oophayngal mucosa. Th capsuls may b takn with without ood. Although an impovmnt may b obsvd at an aly stag, it can tak up t6 months ba spons tth tatmnt can b achivd. Ndos adjustmnt is ncssay in th ldly.

Hat blood pssu mdication such as nicadipin (Cadn) quinidin (Quin-G); o.

Th administation AVODAT in combination with tamsulosin tazosin has nct on th stady-stat phamacokintics ith alpha-adngic antagonist. Th ct administation tamsulosin tazosin on dutastid phamacokintic paamts has not bn valuatd.

O 2,167 mal subjcts tatd with AVODAT in 3 clinical tials, 60% w agd 65 yas and old and 15% w agd 75 yas and old. Novall dincs in saty icacy w obsvd btwn ths subjcts and young subjcts. Oth potd clinical xpinc has not idntiid dincs in sponss btwn th ldly and young patints, but gat snsitivity som old individuals cannot b uld out [s CLINICAL PHAMACOLOGY ].

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