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76 however, the clinical significance of this is unknown, and the risk of metformin-associated lactic acidosis is most commonly attributed to decreased hepatic uptake rather than increased intestinal production.

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Metformin is also available as a liquid for children and people who find it difficult to swallow tabletsLiquid metformin is called by the brand name Riomet.

Yesyou can drink alcohol while taking metforminHoweveralcohol can increase the risk of low blood sugar levelsTry not to drink on an empty stomach.

Over timepeople who have diabetes and high blood sugar can develop serious or life-threatening complicationsincluding heart diseasestrokekidney problemsnerve damageand eye problemsTaking medication(smaking lifestyle changese.gdietexercisequitting smokingand regularly checking your blood sugar may help to manage your diabetes and improve your healthThis therapy may also decrease your chances of having a heart attackstrokeor other diabetes-related complications such as kidney failurenerve damagenumbcold legs or feetdecreased sexual ability in men and womeneye problemsincluding changes or loss of visionor gum diseaseYour doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

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previous reports have shown that metformin does not substantially increase h 2 o 2 production in isolated liver mitochondria and that metformin diminishes mitochondrial h 2 o 2 production in response to paraquat, which induces mitochondrial ros production batandier et al.

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