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You may be prescribed one 40 mg dose of protonix, to be taken daily, for the maintenance of healing for erosive esophagitis.

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CYP2C19 displays a known genetic polymorphism due to its deficiency in some subpopulationse.gapproximately 3of Caucasians and African-Americans and 17to 23of Asians are poor metabolizersAlthough these subpopulations of pantoprazole poor metabolizers have elimination half-life values of 3.5 to 10.0 hours in adultsthey still have minimal accumulation23or lesswith once-daily dosingFor adult patients who are CYP2C19 poor metabolizersno dosage adjustment is needed.

Published observational studies suggest that PPI therapy like Protonix I.Vmay be associated with an increased risk of Clostridium difficileassociated diarrheaespecially in hospitalized patientsThis diagnosis should be considered for diarrhea that does not improvesee Adverse Reactions6.2

In adultssymptomatic response to therapy with Protonix I.Vdoes not preclude the presence of gastric malignancyConsider additional follow-up and diagnostic testing in adult patients who have a suboptimal response or an early symptomatic relapse after completing treatment with a PPIIn older patientsalso consider an endoscopy.

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