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Selegiline should not be used in patients who are being treated with antidepressant drugsincluding MAO inhibitorstricyclic antidepressantsserotonin noradrenaline reuptake inhibitorsSNRIvenlafaxineand selective serotonin reuptake inhibitorse.g citalopramescitalopramfluoxetinefluvoxamineparoxetine and sertralineSee section 4.5 interactions

It is unknown whether selegiline is excreted in human breast milkThe excretion of selegiline in milk has not been studied in animalsPhysico-chemical data on selegiline point to excretion in breast milk and a risk to the suckling child cannot be excludedSelegiline should not be used during breast-feeding.

The combination of selegiline and oral contraceptives or drugs for hormone replacement therapyshould be avoidedas this combination may increase the bioavailability of selegiline.

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in rare cases, generic eldepryl selegiline may cause a hypertensive crisis attack of very high blood pressure .

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